Therapeutic delivery

Antibody-drug conjugates: using monoclonal antibodies for delivery of cytotoxic payloads to cancer cells

VS Goldmacher, YV Kovtun

文献索引：Wolfe, Amanda L.; Duncan, Katharine K.; Lajiness, James P.; Zhu, Kaicheng; Duerfeldt, Adam S.; Boger, Dale L. Journal of Medicinal Chemistry, 2013 , vol. 56, # 17 p. 6845 - 6857

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被引用次数: 38

摘要

... blood, the ADC would be expected to saturate the antigen irrespective of its K d ; ... not those treated with a thioether-linked conjugate, release the highly cytotoxic S-methyl-maytansinoid ... MDR1 (also known as P-glycoprotein or ABCB1), the best-characterized member of the ABC ...