Tetrahedron

Propylphosphonic anhydride (T3P®): an efficient reagent for the one-pot synthesis of 1, 2, 4-oxadiazoles, 1, 3, 4-oxadiazoles, and 1, 3, 4-thiadiazoles

…, S Narasimhan, P Alagarsamy, A Radhakrishnan

文献索引：Augustine, John Kallikat; Vairaperumal, Veeramani; Narasimhan, Sharmila; Alagarsamy, Padma; Radhakrishnan, Anbarasi Tetrahedron, 2009 , vol. 65, # 48 p. 9989 - 9996

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被引用次数: 59

摘要

Propylphosphonic anhydride (T3P ® ) is a highly reactive n-propyl phosphonic acid cyclic anhydride, generally used as a coupling agent and water scavenger with low toxicity and low allergenic potential. 1, 1a and 1b T3P offers several advantages over traditional reagents, such as broad functional group tolerance, low epimerization tendency, easy work up due to water-soluble by-products, and above all it gives high yields and purity. Although T3P has ...