Tetrahedron Letters

An intramolecular cycloaddition approach to pyrrolo [3, 2-c] quinolones

Y He, H Mahmud, BR Wayland, HVR Dias, CJ Lovely

文献索引：He, Yong; Mahmud, Hossen; Wayland, Brian R; Dias, H.V.Rasika; Lovely, Carl J Tetrahedron Letters, 2002 , vol. 43, # 7 p. 1171 - 1174

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被引用次数: 30

摘要

An approach to pyrrolo [3, 2-c] quinolones is described which relies on an intramolecular azomethine ylide alkene cycloaddition reaction. Critical to the success of this reaction was the requirement for alkylation of the aniline nitrogen, in the absence of this substituent a decarboxylative-Michael addition pathway was observed.