Synthesis and biological evaluation of a series of substituted N-alkoxyimides and-amides as potential atypical antipsychotic agents

NJ Hrib, JG Jurcak, FP Huger, CL Errico…

文献索引：Hrib; Jurcak; Huger; Errico; Dunn Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1068 - 1072

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被引用次数: 11

摘要

In a continuing program to discover antipsychotic agents with a reduced propensity toward extrapyramidal side-effects, a series of N-alkoxyimides and-amides was prepared. Evaluation of these compounds in vitro revealed affinities for Dz, 5HTz and 5HTIA receptors. Several members of the series displayed a profile indicative of potential antipsychotic activity in preclinical assays. The most potent compound in these assays, 7, also displayed ...