Small molecule antagonists of the urokinase (uPA): urokinase receptor (uPAR) interaction with high reported potencies show only weak effects in cell-based …

M De Souza, H Matthews, JA Lee, M Ranson…

文献索引：Souza, Melissa De; Matthews, Hayden; Lee, Jodi A.; Ranson, Marie; Kelso, Michael J. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 8 p. 2549 - 2556

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被引用次数: 5

摘要

Abstract Binding of the urokinase-type plasminogen activator (uPA) to its cell-surface-bound receptor uPAR and upregulation of the plasminogen activation system (PAS) correlates with increased metastasis and poor prognosis in several tumour types. Disruptors of the uPA: uPAR interaction represent promising anti-tumour/metastasis agents and several approaches have been explored for this purpose, including the use of small molecule ...