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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Substituent Effects on Oxidation??Induced Formation of Quinone Methides from Arylboronic Ester Precursors

S Cao, R Christiansen, X Peng

文献索引：Cao, Sheng; Christiansen, Robin; Peng, Xiaohua Chemistry - A European Journal, 2013 , vol. 19, # 27 p. 9050 - 9058

全文：HTML全文

被引用次数: 18

摘要

Abstract A series of arylboronic esters containing different aromatic substituents and various benzylic leaving groups (Br or N+ Me 3 Br−) have been synthesized. The substituent effects on their reactivity with H 2 O 2 and formation of quinone methide (QM) have been investigated. NMR spectroscopy and ethyl vinyl ether (EVE) trapping experiments were used to determine the reaction mechanism and QM formation, respectively. QMs were not ...

2-(2-bromomethyl-4-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane结构式

2-(2-bromomethy...

~%

2-(Hydroxymethyl)-2,5-cyclohexadiene-1,4-dione结构式

2-(Hydroxymethy...

2-溴-5-甲氧基甲苯结构式

2-溴-5-甲氧基甲苯

~%

2-(Hydroxymethyl)-2,5-cyclohexadiene-1,4-dione结构式

2-(Hydroxymethy...

2-甲基苯硼酸结构式

2-甲基苯硼酸

~%

(2-hydroxyphenyl)methyl-trimethylazanium,bromide结构式

(2-hydroxypheny...

2-溴甲基苯硼酸频哪醇酯结构式

2-溴甲基苯硼酸频哪醇酯

~%

4,4,5,5-四甲基-1,3,2-二氧杂硼硼烷-2-醇结构式

4,4,5,5-四甲基-1,3...

(2-hydroxyphenyl)methyl-trimethylazanium,bromide结构式

(2-hydroxypheny...

N,N,N-Trimethyl-1-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanaminium bromide结构式

N,N,N-Trimethyl...

~%

4,4,5,5-四甲基-1,3,2-二氧杂硼硼烷-2-醇结构式

4,4,5,5-四甲基-1,3...

(2-hydroxyphenyl)methyl-trimethylazanium,bromide结构式

(2-hydroxypheny...

4,4,5,5-四甲基-2-(邻甲苯基)-1,3,2-二氧环戊硼烷结构式

4,4,5,5-四甲基-2-(...

~%

4,4,5,5-四甲基-1,3,2-二氧杂硼硼烷-2-醇结构式

4,4,5,5-四甲基-1,3...

(2-hydroxyphenyl)methyl-trimethylazanium,bromide结构式

(2-hydroxypheny...

2-(羟甲基)-4-甲氧基苯酚结构式

2-(羟甲基)-4-甲氧基苯酚

~%

2-(hydroxymethyl)benzene-1,4-diol结构式

2-(hydroxymethy...

2-(2-bromomethyl-4-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane结构式

2-(2-bromomethy...

~%

2-(hydroxymethyl)benzene-1,4-diol结构式

2-(hydroxymethy...

2-溴-5-甲氧基甲苯结构式

2-溴-5-甲氧基甲苯

~%

2-(hydroxymethyl)benzene-1,4-diol结构式

2-(hydroxymethy...

2-溴-5-硝甲苯结构式

2-溴-5-硝甲苯

双戊酰二硼结构式

双戊酰二硼

~85%

2-甲基-4-硝基苯基硼酸,频哪醇酯结构式

2-甲基-4-硝基苯基硼酸,频哪醇酯

2-(2-bromomethyl-4-nitrophenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane结构式

2-(2-bromomethy...

~28%

2-羟基-5-硝基苯甲醇结构式

2-羟基-5-硝基苯甲醇

1,3-dihydro-5-nitro-1-hydroxy-2,1-benzoxaborole结构式

1,3-dihydro-5-n...

未登录结构式

2-甲基-4-硝基苯基硼酸,频哪醇酯结构式

2-甲基-4-硝基苯基硼酸,频哪醇酯

~%

2-羟基-5-硝基苯甲醇结构式

2-羟基-5-硝基苯甲醇

1,3-dihydro-5-nitro-1-hydroxy-2,1-benzoxaborole结构式

1,3-dihydro-5-n...

未登录结构式

2-溴-5-硝甲苯结构式

2-溴-5-硝甲苯

~%

2-羟基-5-硝基苯甲醇结构式

2-羟基-5-硝基苯甲醇

1,3-dihydro-5-nitro-1-hydroxy-2,1-benzoxaborole结构式

1,3-dihydro-5-n...

未登录结构式

乙烯基乙醚结构式

乙烯基乙醚

2-溴甲基苯硼酸频哪醇酯结构式

2-溴甲基苯硼酸频哪醇酯

~3%

2-乙氧基苯并二氢吡喃结构式

2-乙氧基苯并二氢吡喃

2-甲基苯硼酸结构式

2-甲基苯硼酸

~%

2-乙氧基苯并二氢吡喃结构式

2-乙氧基苯并二氢吡喃

4,4,5,5-四甲基-2-(邻甲苯基)-1,3,2-二氧环戊硼烷结构式

4,4,5,5-四甲基-2-(...

~%

2-乙氧基苯并二氢吡喃结构式

2-乙氧基苯并二氢吡喃

双戊酰二硼结构式

双戊酰二硼

~%

4,4,5,5-四甲基-1,3,2-二氧杂硼硼烷-2-醇结构式

4,4,5,5-四甲基-1,3...

2-甲基-4-硝基苯基硼酸,频哪醇酯结构式

2-甲基-4-硝基苯基硼酸,频哪醇酯

~%

4,4,5,5-四甲基-1,3,2-二氧杂硼硼烷-2-醇结构式

4,4,5,5-四甲基-1,3...

2-(2-bromomethyl-4-methylphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane结构式

2-(2-bromomethy...

~%

4,4,5,5-四甲基-1,3,2-二氧杂硼硼烷-2-醇结构式

4,4,5,5-四甲基-1,3...

2-(2-bromomethyl-4-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane结构式

2-(2-bromomethy...

~%

4,4,5,5-四甲基-1,3,2-二氧杂硼硼烷-2-醇结构式

4,4,5,5-四甲基-1,3...

2-(2-bromomethyl-4-nitrophenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane结构式

2-(2-bromomethy...

~%

4,4,5,5-四甲基-1,3,2-二氧杂硼硼烷-2-醇结构式

4,4,5,5-四甲基-1,3...

2-溴甲基-4-氟苯硼酸频哪醇酯结构式

2-溴甲基-4-氟苯硼酸频哪醇酯

~%

4,4,5,5-四甲基-1,3,2-二氧杂硼硼烷-2-醇结构式

4,4,5,5-四甲基-1,3...

未登录结构式

~%

4,4,5,5-四甲基-1,3,2-二氧杂硼硼烷-2-醇结构式

4,4,5,5-四甲基-1,3...

trimethyl-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-methoxybenzyl]-quaternaryammonium bromide结构式

trimethyl-[2-(4...

~%

4,4,5,5-四甲基-1,3,2-二氧杂硼硼烷-2-醇结构式

4,4,5,5-四甲基-1,3...

未登录结构式

~%

4,4,5,5-四甲基-1,3,2-二氧杂硼硼烷-2-醇结构式

4,4,5,5-四甲基-1,3...

trimethyl-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-fluorobenzyl]-quaternaryammonium bromide结构式

trimethyl-[2-(4...

~%

4,4,5,5-四甲基-1,3,2-二氧杂硼硼烷-2-醇结构式

4,4,5,5-四甲基-1,3...

2-溴甲基苯硼酸频哪醇酯结构式

2-溴甲基苯硼酸频哪醇酯

~%

4,4,5,5-四甲基-1,3,2-二氧杂硼硼烷-2-醇结构式

4,4,5,5-四甲基-1,3...

(2-hydroxyphenyl)methyl-trimethylazanium,bromide结构式

(2-hydroxypheny...

2-(2-bromomethyl-4-methylphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane结构式

2-(2-bromomethy...

~%

4,4,5,5-四甲基-1,3,2-二氧杂硼硼烷-2-醇结构式

4,4,5,5-四甲基-1,3...

未登录结构式

2-(2-bromomethyl-4-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane结构式

2-(2-bromomethy...

~%

4,4,5,5-四甲基-1,3,2-二氧杂硼硼烷-2-醇结构式

4,4,5,5-四甲基-1,3...

未登录结构式

N,N,N-Trimethyl-1-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanaminium bromide结构式

N,N,N-Trimethyl...

~%

4,4,5,5-四甲基-1,3,2-二氧杂硼硼烷-2-醇结构式

4,4,5,5-四甲基-1,3...

(2-hydroxyphenyl)methyl-trimethylazanium,bromide结构式

(2-hydroxypheny...

未登录结构式

~%

4,4,5,5-四甲基-1,3,2-二氧杂硼硼烷-2-醇结构式

4,4,5,5-四甲基-1,3...

未登录结构式

trimethyl-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-methoxybenzyl]-quaternaryammonium bromide结构式

trimethyl-[2-(4...

~%

4,4,5,5-四甲基-1,3,2-二氧杂硼硼烷-2-醇结构式

4,4,5,5-四甲基-1,3...

未登录结构式

4,4,5,5-四甲基-2-(邻甲苯基)-1,3,2-二氧环戊硼烷结构式

4,4,5,5-四甲基-2-(...

~%

4,4,5,5-四甲基-1,3,2-二氧杂硼硼烷-2-醇结构式

4,4,5,5-四甲基-1,3...

(2-hydroxyphenyl)methyl-trimethylazanium,bromide结构式

(2-hydroxypheny...

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