Discovery of pyrazolo [1, 5-a] pyrimidine-based CHK1 inhibitors: A template-based approach—Part 2

M Labroli, K Paruch, MP Dwyer, C Alvarez…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 1 p. 471 - 474

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被引用次数: 28

摘要

... Bioorganic & Medicinal Chemistry Letters. ... As discussed in the preceding Letter, 5 the SAR study of the C3 position demonstrated that the 4-N-methylpyrazole moiety conferred optimal CHK1 potency while maintaining selectivity against CDK2. ...