New acridine derivatives bearing two symmetrical imidazolidinone rings, 3, 6-bis ((1-alkyl-5- oxo-imidazolidin-2-yliden) imino) acridine hydrochlorides 6a–6e (alkyl= ethyl, n-propyl, n- butyl, n-pentyl, n-hexyl), have been prepared and their interactions with calf thymus DNA and selected cell lines were studied. The DNA-binding of 6a–6e to ctDNA was examined by UV–vis, fluorescence, and CD spectroscopy. The binding constants determined by UV–vis ...
