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Benzenesulfenamides as antihypertensive agents. Substituted piperidine and 1-arylpiperazine derivatives

…, RC Allen, JC Wilker, DL Woodward

文献索引:Klioze; Allen; Wilker; Woodward Journal of Medicinal Chemistry, 1980 , vol. 23, # 6 p. 677 - 679

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被引用次数: 14

摘要

The synthesis and antihypertensive activity of several piperidinebenzenesulfenamides related to the previously reported potent hypotensive agent 1 and a series of 1- arylpiperazine-4-benzenesulfenamides 7 are described. A number of the latter compounds exhibit marked antihypertensive properties. The most interesting of these compounds, 7a and 7k, have been evaluated in several other animal models. In addition, ...