Tetrahedron

Biocatalytic racemization of α-hydroxycarboxylic acids using a stereo-complementary pair of α-hydroxycarboxylic acid dehydrogenases

…, SM Glueck, BM Nestl, CC Gruber, N Baudendistel…

文献索引：Bodlenner, Anne; Glueck, Silvia M.; Nestl, Bettina M.; Gruber, Christian C.; Baudendistel, Nina; Hauer, Bernhard; Kroutil, Wolfgang; Faber, Kurt Tetrahedron, 2009 , vol. 65, # 36 p. 7752 - 7755

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被引用次数: 7

摘要

Biocatalytic racemization of aliphatic,(aryl) aliphatic and aromatic α-hydroxycarboxylic acids was achieved via a reversible oxidation-reduction sequence using a pair of stereo- complementary Prelog-and anti-Prelog d-and l-α-hydroxyisocaproate dehydrogenases from Lactobacillus confusus DSM 20196 and Lactobacillus paracasei DSM 20008, resp., overexpressed in Escherichia coli. The mild reaction conditions ensured essential 'clean' ...