Synthesis

A New Two-Step Synthesis of 2-Alkylated 1, 4-Diketones and α-Alkylated γ-Keto Esters

R Ballini, G Bosica, L Petrelli, M Petrini

文献索引：Ballini; Bosica; Petrelli; Petrini Synthesis, 1999 , # 7 p. 1236 - 1240

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被引用次数: 19

摘要

Abstract: 2-Alkylated 1, 4-diketones and a-alkylated g-keto esters can be easily prepared by a two-step procedure which involves first the conjugate addition of a nitroalkane to an enedione derivative in acetonitrile with DBU as base, followed by chemoselective hydrogenation of the C–C double bond (H2, 10% Pd/C) of the Michael adduct, obtained after elimination of nitrous acid. Key words: 2-Alkyl 1, 4-diketones, a-alkyl g-keto esters, ...