Highly regioselective catalytic oxidative coupling reactions: synthetic and mechanistic investigations

KL Hull, EL Lanni, MS Sanford

文献索引：Hull, Kami L.; Lanni, Erica L.; Sanford, Melanie S. Journal of the American Chemical Society, 2006 , vol. 128, # 43 p. 14047 - 14049

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被引用次数: 263

摘要

A highly efficient and regioselective Pd-catalyzed method for the oxidative coupling of arylpyridine derivatives is reported. Remarkably, the reactions proceed at room temperature and are compatible with diverse functionalities, including aryl halides and thiophenes. Mechanistic studies suggest that these transformations proceed via a previously unprecedented mechanism involving two different pyridine-directed CH activation ...