Bronchodilator and antiulcer phenoxypyrimidinones

…, JG Stam, JN Pereira, NR Ackerman…

文献索引：Lipinski, C. A.; Stam, J. G.; Pereira, J. N.; Ackerman, N. R.; Hess, H.-J. Journal of Medicinal Chemistry, 1980 , vol. 23, # 9 p. 1026 - 1031

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被引用次数: 22

摘要

Series of 5-phenoxy-2 (1H)-pyrimidinones, 5-phenoxy-4 (3H)-pyrimidinones, and related compounds were prepared in a follow-up of a lead prepared as a potential cyclic nucleotide regulating agent. Compounds were evaluated for bronchodilator activity in histamine- challenged guinea pigs and for antiulcer activity in a cold-restraint, stressed rat ulcer model. Bronchodilator activity comparable to, or greater than, that of theophylline was found in ...