Synthesis of 2, 3, 4, 5-tetrasubstituted pyrroles from aromatic ketoximes using the TiCl4/Et3N reagent system

…, G Srinivas, M Seenivasaperumal

文献索引：Periasamy, Mariappan; Srinivas, Gadthula; Seenivasaperumal, Muthu Journal of Chemical Research, 2004 , # 4 p. 270 - 272

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摘要

Pyrroles are an important class of heterocycle.1 Symmetrically substituted pyrroles are usually prepared through methods involving the corresponding ketazine intermediate,2 rearrangement of ketazine dianions,3 and using ketones and alkyl hydrazines.4 In the course of studies on the synthetic applications of the TiCl4/Et3N reagent system,5 we have discovered, and report here, a convenient one-pot synthesis of 2,3,4, 5-tetrasubstituted pyrroles from aromatic ...