Molecular basis of the selective binding of MDMA enantiomers to the alpha4beta2 nicotinic receptor subtype: Synthesis, pharmacological evaluation and mechanistic …
…, E Cristóbal-Lecina, A Riera, JI Borrell…
文献索引：Llabres, Salome; Garcia-Rates, Sara; Cristobal-Lecina, Edgar; Riera, Antoni; Borrell, Jose Ignacio; Camarasa, Jorge; Pubill, David; Luque, F. Javier; Escubedo, Elena European Journal of Medicinal Chemistry, 2014 , vol. 81, p. 35 - 46
Abstract The α4β2 nicotinic acetylcholine receptor (nAChR) is a molecular target of 3, 4- methylenedioxymethamphetamine (MDMA), a synthetic drug also known as ecstasy, and it modulates the MDMA-mediated reinforcing properties. However, the enantioselective preference of the α4β2 nAChR subtype still remains unknown. Since the two enantiomers exhibit different pharmacological profiles and stereoselective metabolism, the aim of this ...
