Synthesis of analogs of the antibiotic phervenulin and its 4-oxide

…, EL Pidémskii, AF Goleneva, GA Aleksandrova

文献索引：Azev, Yu. A.; Vereshchagina, N. N.; Pidemskii, E. L.; Goleneva, A. F.; Aleksandrova, G. A. Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 5 p. 322 - 325 Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 5 p. 573 - 576

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摘要

With respect to their anticonvulsant activity, la-h and lla-h resemble the previously described [i] 5-(p-alkoxyphenyl)-5-methylhydantoins, for which anticorazole properties are also characteristic. In addition to this, lla, b, with SI= 8.3 and 8.6 and TI= i0 and 10.5, respectively, are appreciably inferior to the most active compound IV, the'Sl and TI of which are 14.3 and 14.3, respectively (see Table 4). Morpholino and dimorpholino groupings evidently do not ...