Synthesis of a directly connected thiazole-oxazole ring system present in microcin B17

G Li, PM Warner, DJ Jebaratnam

文献索引：Li, Gang; Warner, Philip M.; Jebaratnam, David J. Journal of Organic Chemistry, 1996 , vol. 61, # 2 p. 778 - 780

全文：HTML全文

被引用次数: 18

摘要

Microcin B17 (McB17) is a 43 residue peptide antibiotic ribosomally synthesized in several strains of Escherichia coli. 1 Recently, we2 and others3 have reported that fourteen of these residues are posttranslationally modified; two Gly-Cys and Gly-Ser dipeptides lead, respectively, to two isolated thiazole and oxazole rings, whereas two tripeptides Gly-Cys-Ser and Gly-Ser-Cys produce two directly connected thiazole-oxazole ring systems. The ...