Consequently, the polybromination of the imidazole ring is of high synthetic interest and efforts have to be made to develop this reaction. The pioneering works by Pyman 7 using bromine in refluxing chloroform only led to poor yields. This was attributed to the formation of the hydrobromide and subsequent degradations. 8 Such side-reactions drew other authors to use basic media for the neutralization of hydrogen bromide formed along the reaction. Indeed using an ...
