Probing binding and cellular activity of pyrrolidinone and piperidinone small molecules targeting the urokinase receptor

…, D Liu, D Zhou, L Li, WE Knabe, F Wang, K Oh…

文献索引：Mani, Timmy; Liu, Degang; Zhou, Donghui; Li, Liwei; Knabe, William Eric; Wang, Fang; Oh, Kyungsoo; Meroueh, Samy O. ChemMedChem, 2013 , vol. 8, # 12 p. 1963 - 1977

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被引用次数: 3

摘要

Abstract The urokinase receptor (uPAR) is a cell-surface protein that is part of an intricate web of transient and tight protein interactions that promote cancer cell invasion and metastasis. Here, we evaluate the binding and biological activity of a new class of pyrrolidinone and piperidinone compounds, along with derivatives of previously-identified pyrazole and propylamine compounds. Competition assays revealed that the compounds ...