Synthesis and biological properties of thiazole-analogues of pyochelin, a siderophore of Pseudomonas aeruginosa

S Noel, F Hoegy, F Rivault, D Rognan, IJ Schalk…

文献索引：Noel, Sabrina; Hoegy, Francoise; Rivault, Freddy; Rognan, Didier; Schalk, Isabelle J.; Mislin, Gaetan L.A. Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 132 - 135

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摘要

Abstract Pyochelin is a siderophore common to all strains of Pseudomonas aeruginosa utilized by this Gram-negative bacterium to acquire iron (III). FptA is the outer membrane transporter responsible of ferric-pyochelin uptake in P. aeruginosa. We describe in this Letter the synthesis and the biological properties (55 Fe uptake, binding to FptA) of several thiazole analogues of pyochelin. Among them we report in this Letter the two first ...