Synthesis and selective human monoamine oxidase inhibition of 3-carbonyl, 3-acyl, and 3-carboxyhydrazido coumarin derivatives

…, S Carradori, A Bolasco, P Chimenti, M Yáñez…

文献索引：Secci, Daniela; Carradori, Simone; Bolasco, Adriana; Chimenti, Paola; Yanez, Matilde; Ortuso, Francesco; Alcaro, Stefano European Journal of Medicinal Chemistry, 2011 , vol. 46, # 10 p. 4846 - 4852

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被引用次数: 46

摘要

Several 3-carbonyl (1–26), 3-acyl (27–52), and 3-carboxyhydrazido (53–58) coumarins have been synthesized in high yields (72–99%) and tested in vitro for their human monoamine oxidase A and B (hMAO-A and hMAO-B) inhibitory activity. Different substituents on the coumarin nucleus were evaluated for their effect on biological activity and isoform selectivity. Substitution at position C7 of the 3-ethyl ester coumarin ring, or the introduction ...