前往化源商城

Helvetica chimica acta

Orthocarbonsäure??ester mit 2, 4, 10??Trioxaadamantanstruktur als Carboxylschutzgruppe; Verwendung zur Synthese von substituierten Carbonsäuren mit Hilfe von …

G Voss, H Gerlach

文献索引:Voss, Gundula; Gerlach, Hans Helvetica Chimica Acta, 1983 , vol. 66, # 7 p. 2294 - 2307

全文:HTML全文

被引用次数: 33

摘要

Summary The surprising stability of 2, 4, lO-trioxa-3-adamantyl derivatives 1 against nucleophilic substitution by organomagnesium compounds is discussed and shown to be caused by unfavourable stereoelectronic and steric factors governing the substitution of these cage compounds (Scheme 2). As a consequence, a number of Grignard reagents 2 containing the carboxyl group masked as 2, 4, 10-trioxa-3-adamantyl group could be ...

 相关合成线路

~83%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~94%

~%

~%

~%

~%

~%

~%

~%

~10%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~92%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~%

~91%

~%

~%

~%

~78%

~%

~%

~%

~%

~%

~%

~30%

~91%

~%