Structure-activity Relationships for α-Glucosidase Inhibition of Baicalein, 5, 6, 7-Trihydroxyflavone: the Effect of A-Ring Substitution

…, T NISHIOKA, J Kawabata, T KASAI

文献索引：Gao, Hong; Nishioka, Tetsuo; Kawabata, Jun; Kasai, Takanori Bioscience, Biotechnology and Biochemistry, 2004 , vol. 68, # 2 p. 369 - 375

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被引用次数: 4

摘要

In order to estimate the effects of the A-ring hydroxyl group of baicalein (5, 6, 7- trihydroxyflavone, 1) on rat intestinal α-glucosidase inhibition, flavone, monohydroxyflavones, dihydroxyflavones, and methylated derivatives of 5, 6, 7- trihydroxyflavone were used for the structure-activity relationship (SAR) study. The importance of the 6-hydroxyl group of baicalein was validated for an exertion of the activity ...