Tetrahedron letters

Room temperature dehalogenation of chloroarenes by polymethylhydrosiloxane (PMHS) under palladium catalysis

RJ Rahaim, RE Maleczka

文献索引：Rahaim Jr., Ronald J.; Maleczka Jr., Robert E. Tetrahedron Letters, 2002 , vol. 43, # 49 p. 8823 - 8826

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被引用次数: 50

摘要

The first method for the reduction of chloroarenes by polymethylhydrosiloxane (PMHS) is reported. Catalytic amounts of palladium (II) acetate in combination with PMHS and aqueous KF will rapidly hydrodehalogenate aryl chlorides at room temperature. The mildness of the method is demonstrated by its tolerance of ketones, amides, esters, nitriles, ethers, borate esters, and amines.