Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals

JR Dunetz, J Magano…

文献索引：Ikemoto, Tomomi; Ito, Tatsuya; Hashimoto, Hideo; Kawarasaki, Tadao; Nishiguchi, Atsuko; Mitsudera, Hiroyuki; Wakimasu, Mitsuhiro; Tomimatsu, Kiminori Organic Process Research and Development, 2000 , vol. 4, # 6 p. 520 - 525

全文：HTML全文

被引用次数: 22

摘要

... Amide bonds are very frequently incorporated into active pharmaceutical ingredients (API).(2) In fact ... an amine can be implemented under anhydrous conditions using an organic base, such ... Thionyl chloride is the most common reagent in process chemistry for the conversion of ...