Probing the aglycon promiscuity of an engineered glycosyltransferase

…, RD Goff, GJ Williams, JS Thorson

文献索引：Gantt, Richard W.; Goff, Randal D.; Williams, Gavin J.; Thorson, Jon S. Angewandte Chemie - International Edition, 2008 , vol. 47, # 46 p. 8889 - 8892

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被引用次数: 80

摘要

Sugars appended to pharmaceutically important natural products influence their key pharmacological properties and/or molecular mechanisms of action.[1] However, studies designed to systematically understand or exploit the role of carbohydrates in drug discovery are often limited by the availability of practical synthetic and biosynthetic tools.[2] Among the contemporary options to address this limitation,[3–4] chemoenzymatic glycorandomization ...