Synthesis of N-(tert-Butyloxycarbonyl)-CBI, CBI, CBI-CDPI1, and CBI-CDPI2: Enhanced Functional Analogs of CC-1065 Incorporating the 1, 2, 9, 9a- …

…, T Ishizaki, PA Kitos, O Suntornwat

文献索引：Boger, Dale L.; Ishizaki, Takayoshi; Kitos, Paul A.; Suntornwat, Oranart Journal of Organic Chemistry, 1990 , vol. 55, # 23 p. 5823 - 5832

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被引用次数: 124

摘要

Full details of the synthesis of N-(tert-butyloxycarbonyl)-1, 2, 9, 9a-tetr~ ydrocyclopropa [c] benz [e] indol-4-one [N-BOC-CBI (6)] constituting a more stable functional analogue of the CC-1065 left-hand subunit are described. The resolution of an immediate CBI synthetic precursor,(+)-and (-)-14, the unambiguous establishment of the absolute configuration, and the incorporation of (d=)-,(+)-, and (-)-14 into the synthesis of racemic and optically active ...