Sugar-linked dithiocarbamates as modulators of metabolic and genotoxic properties of N-nitroso compounds

BH Lee, B Bertram, P Schmezer, N Frank…

文献索引：Lee; Bertram; Schmezer; Frank; Wiessler Journal of Medicinal Chemistry, 1994 , vol. 37, # 19 p. 3154 - 3162

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被引用次数: 12

摘要

A series of putative anticarcinogenic and antimutagenic compounds was synthesized on the basis of tetraethylthiuram disulfide (disulfiram) and its metabolite, diethyldithiocarbamate (DDTC). Diallyldithiocarbamate was synthesized in order to combine the anticarcinogenic properties of diallyl sulfide, a known inhibitor of chemical carcinogenesis from Allium species, and those of DDTC. Several sugar-linked dithiocarbamates (SDTCs) were ...