Tetrahedron Letters

Synthesis and solid state study of pyridine-and pyrimidine-based fragment libraries

J Spencer, H Patel, SK Callear, SJ Coles…

文献索引：Spencer, John; Patel, Hiren; Callear, Samantha K.; Coles, Simon J.; Deadman, John J. Tetrahedron Letters, 2011 , vol. 52, # 45 p. 5905 - 5909

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被引用次数: 6

摘要

A library of pyridines and pyrimidines has been synthesised in excellent yields employing microwave and flow chemistry methodologies. Work-up bottlenecks have been facilitated substantially by the use of supported reagents and many of the final compounds have been studied in the solid state by single crystal X-ray diffraction.