High yield synthesis of 4H??1, 4??benzothiazine??1, 1??dioxide derivatives

S De Montis, C Fattuoni, E Cadoni…

文献索引：De Montis, Stefania; Fattuoni, Claudia; Cadoni, Enzo; Cabiddu, Maria G.; Usai, Michele; Cabiddu, Salvatore Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 5 p. 1445 - 1449

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被引用次数: 5

摘要

1, 4-Benzothiazine derivatives have drawn much interest in the pharmacologic field due to their structural similarity with the phenothiazine system [1]. In particular the synthesis of the S- oxidized system, 4H-1, 4-benzothiazine-1, 1-dioxide, has been the object of several studies and patents for industrial and pharmacological applications [2-5]. The synthesis of such systems usually started from 2-aminobenzenethiols which were treated with β-diketones ...