Efficient chemical conversion of louisianin A to C and D, the inhibitor of angiogenesis.

…, T ZHI-MING, Y HARIGAYA, S TAKAMATSU…

文献索引：Sunazuka, Toshiaki; Zhi-Ming, Tian; Harigaya, Yoshihiro; Takamatsu, Satoshi; Hayashi, Masahiko; Komiyama, Kanki; Omura, Satoshi Journal of Antibiotics, 1997 , vol. 50, # 3 p. 274 - 275

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被引用次数: 13

摘要

(POC13) at 120~ 125 C3) to obtain chloro derivative (2) in 86% yield. 2 was reduced by Zn- AcOHat 50 C4) to afford 3 (52% yield) and 4 (35% yield). Furthermore, under the samecondition, 3 was dechlorinated to give 4 in 48% yield. Moreover, 4 was oxidized in the treatment of CrO3-pyridine5) to obtain louisianin C (5) in 75% yield. Finally, 5 was treated with 1, 8-diazabicyclo-[5, 4, 0]-undec-7-ene (DBU) in benzene at 85 C6) to obtain ...