Chemical research in toxicology

Structural definition of early lysine and histidine adduction chemistry of 4-hydroxynonenal

DV Nadkarni, LM Sayre

文献索引：Nadkarni, Durgesh V.; Sayre, Lawrence M. Chemical Research in Toxicology, 1995 , vol. 8, # 2 p. 284 - 291

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被引用次数: 243

摘要

The lipid peroxidation product trarzs-4-hydroxy-2-nonenal(HNE) has been implicated in the covalent modification of low-density lipoproteins (LDL) thought to contribute to the overaccumulation of LDL in the arterial wall in the initial stages of atherosclerosis. Proposals for the exact structures of “early” protein side-chain modifications until now have been based on indirect evidence. In this paper, the structures of first-formed His-and Lys-based ...