Orally bioavailable nonpeptide vitronectin receptor antagonists containing 2-aminopyridine arginine mimetics

RM Keenan, WH Miller, LS Barton, WE Bondinell…

文献索引：Keenan, Richard M.; Miller, William H.; Barton, Linda S.; Bondinell, William E.; Cousins, Russell D.; Eppley, Daniel F.; Hwang, Shing-Mei; Kwon, Chet; Lago, M. Amparo; Nguyen, Thomas T.; Smith, Brian R.; Uzinskas, Irene N.; Yuan, Catherine C. K. Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 13 p. 1801 - 1806

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被引用次数: 39

摘要

A peptide RGD analog containing a novel 2-aminopyridine arginine mimetic was discovered to have good affinity and selectivity for the vitronectin receptor. Incorporation of the 2- aminopyridine arginine mimetic into the 3-oxo-1, 4-benzodiazepine-2-acetic acid integrin antagonist series led to novel and potent nonpeptide vitronectin receptor antagonists with promising levels of oral bioavailability.