Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors

…, V Zuco, M De Cesare, F Zunino, S Dallavalle

文献索引：Cincinelli, Raffaella; Musso, Loana; Giannini, Giuseppe; Zuco, Valentina; De Cesare, Michelandrea; Zunino, Franco; Dallavalle, Sabrina European Journal of Medicinal Chemistry, 2014 , vol. 79, p. 251 - 259

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被引用次数: 7

摘要

Abstract To investigate the influence of the adamantyl group on the biological properties of known HDAC inhibitors with a 4-phenylcinnamic skeleton, a series of compounds having the adamantyl moiety in the cap structure were synthesized and compared to the corresponding hydroxamic acids lacking this group. An unexpected finding was the substantial reduction of inhibitory activity toward the tested enzymes, in particular HDAC6, following the ...