Novel biocatalytic reduction of aryl azides: chemoenzymaticsynthesis of pyrrolo [2, 1-c][1, 4] benzodiazepineantibiotics1

…, BSN Reddy, B Lakminarayana, BSP Reddy

文献索引：Kamal, Ahmed; Damayanthi; Reddy, B. S. Narayan; Lakminarayana; Reddy, B. S. Praveen Chemical Communications, 1997 , # 11 p. 1015 - 1016

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被引用次数: 36

摘要

The chemoselective reduction of aryl azides to aryl amines, and the synthesis of the imine- containing pyrrolo [2, 1-c]-[1, 4] benzodiazepine DNA-binding antitumour antibiotics by selective biocatalytic reductive cyclization of azido aldehydes, has been achieved by employing baker's yeast.