Design and Synthesis of 2??Phenoxynicotinic Acid Hydrazides as Anti??inflammatory and Analgesic Agents

…, H Sadeghian, H Shadnia, O Firouzi, R Miri…

文献索引：Moradi, Alireza; Navidpour, Latifeh; Amini, Mohsen; Sadeghian, Hamid; Shadnia, Hooman; Firouzi, Omidreza; Miri, Ramin; Ebrahimi, Seyed Esmaeil Sadat; Abdollahi, Mohammad; Zahmatkesh, Mona Haddad; Shafiee, Abbas Archiv der Pharmazie, 2010 , vol. 343, # 9 p. 509 - 518

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被引用次数: 14

摘要

Abstract A series of 2-phenoxynicotinic acid hydrazides were synthesized and evaluated for their analgesic and anti-inflammatory activities. Several compounds having an unsubstituted phenyl/4-pyridyl or C-4 methoxy substituent on the terminal phenyl ring showed moderate to high analgesic or anti-inflammatory activity in comparison to mefenamic acid as the reference drug. The compounds with highest anti-inflammatory activity were subjected to ...