A novel asymmetric route to 2-amino-1, 2, 3, 4-tetrahydronaphthalenes

…, M Jackson, IC Lennon, JA Ramsden, H Samuel

文献索引：Harris, Michael C. J.; Jackson, Mark; Lennon, Ian C.; Ramsden, James A.; Samuel, Helen Tetrahedron Letters, 2000 , vol. 41, # 17 p. 3187 - 3191

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被引用次数: 16

摘要

The pharmacological activity of 2-amino-1,2,3,4-tetrahydronaphthalenes (2-aminotetralins) is well known. 1 The 2-aminotetralin structure is most commonly accessed from the corresponding 2-tetralone either via reductive amination 2 or oxime reduction. 3 Two asymmetric routes have been reported, namely the hydrogenation of an enamide derived from a 2-tetralone, 4 and the cyclisation of homo-phenylalanine derivatives. 5 Here we report an alternative ...