A Facile and Efficient Multi??Gram Synthesis of N??Protected 5??(Guanidinocarbonyl)??1H??pyrrole??2??carboxylic Acids

…, L Geiger, D Rupprecht, J Dudaczek…

文献索引：Schmuck, Carsten; Bickert, Volker; Merschky, Michael; Geiger, Lars; Rupprecht, Daniel; Dudaczek, Juergen; Wich, Peter; Rehm, Thomas; Machon, Uwe European Journal of Organic Chemistry, 2008 , # 2 p. 324 - 329

全文：HTML全文

被引用次数: 24

摘要

Abstract The synthesis of two versatile building blocks for supramolecular anion binding motifs, 5-(N-Boc-guanidinocarbonyl)-1H-pyrrole-2-carboxylic acid (1) and 5-(N-Cbz- guanidinocarbonyl)-1H-pyrrole-2-carboxylic acid (2) is reported. Using these building blocks, a guanidiniocarbonyl-pyrrole anion binding site can easily be introduced into more complex molecules by using standard amide coupling conditions. Both syntheses can be ...