Tetrahedron

Formal total synthesis of (−)-spongidepsin

S Chandrasekhar, SR Yaragorla, L Sreelakshmi…

文献索引：Chandrasekhar; Yaragorla; Sreelakshmi; Reddy, Ch. Raji Tetrahedron, 2008 , vol. 64, # 22 p. 5174 - 5183

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被引用次数: 31

摘要

The formal total synthesis of (−)-spongidepsin is described. Three fragments I, II, and III were first prepared from readily available starting materials and then assembled to the target compound. The key steps involved in the synthesis are asymmetric α-hydroxylation, Ender's alkylation, and ring-closing metathesis reactions. An alternative route for the fragment II is also achieved involving Sharpless asymmetric epoxidation and Gilman's alkylation as key ...