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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Antiinflammatory activity of 5, 6-diaryl-2, 3-dihydroimidazo [2, 1-b] thiazoles. Isomeric 4-pyridyl and 4-substituted-phenyl derivatives

…, KA Razgaitis, BM Sutton, MJ DiMartino…

文献索引：Lantos, I.; Bender, P. E.; Razgaitis, K. A.; Sutton, B. M.; DiMartino, M. J.; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 72 - 75

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被引用次数: 73

摘要

a Tested at 50 mg/kg, PO.* Tested at 25 mg/kg, PO. Active 1 out of 3 times tested. p= 0.05, as judged by Student's t test. ep= 0.01, as judged by Student's t test. fp= 0.001, as judged by Student's t test. g NS= not significant; p> 0.05, as judged by Student's t test. and to incorporate 4-pyridyl substituents into the series. Chemistry. Unsymmetrically substituted imidazo-[2,141 thiazoles (6a, b) were prepared regioselectively by condensation of ...

4-甲氧基苯基乙酰氯结构式

4-甲氧基苯基乙酰氯

苯结构式

~%

2-(4-甲氧基苯基)苯乙酮结构式

2-(4-甲氧基苯基)苯乙酮

对氟苯甲醛结构式

对氟苯甲醛

benzoyloxy-[4]pyridyl-acetonitrile结构式

benzoyloxy-[4]p...

~%

1-(4-fluorophenyl)-2-hydroxy-2-pyridin-4-ylethanone结构式

1-(4-fluorophen...

[1-(4-methoxyphenyl)-2-oxo-2-pyridin-4-ylethyl] benzoate结构式

[1-(4-methoxyph...

2-(4-甲氧基苯基)苯乙酮结构式

2-(4-甲氧基苯基)苯乙酮

~63%

2-bromo-2-(4-methoxyphenyl)-1-phenylethanone结构式

2-bromo-2-(4-me...

4-甲氧基苯基乙酰氯结构式

4-甲氧基苯基乙酰氯

~%

2-bromo-2-(4-methoxyphenyl)-1-phenylethanone结构式

2-bromo-2-(4-me...

苯结构式

~%

2-bromo-2-(4-methoxyphenyl)-1-phenylethanone结构式

2-bromo-2-(4-me...

1-(4-fluorophenyl)-2-hydroxy-2-pyridin-4-ylethanone结构式

1-(4-fluorophen...

~%

6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑结构式

6-(4-氟苯基)-5-(4-...

4-(4-fluorophenyl)-5-pyridin-4-yl-1,3-dihydroimidazole-2-thione结构式

4-(4-fluorophen...

1,2-二溴乙烷结构式

1,2-二溴乙烷

~%

6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑结构式

6-(4-氟苯基)-5-(4-...

5-(4-fluorophenyl)-6-pyridin-4-yl-2,3-dihydroimidazo[2,1-b][1,3]thiazole结构式

5-(4-fluorophen...

4-吡啶甲醛结构式

~%

6-(4-methoxyphenyl)-5-pyridin-4-yl-2,3-dihydroimidazo[2,1-b][1,3]thiazole结构式

6-(4-methoxyphe...

2-hydroxy-1-(4-methoxyphenyl)-2-pyridin-4-ylethanone结构式

2-hydroxy-1-(4-...

~%

6-(4-methoxyphenyl)-5-pyridin-4-yl-2,3-dihydroimidazo[2,1-b][1,3]thiazole结构式

6-(4-methoxyphe...

benzoyloxy-[4]pyridyl-acetonitrile结构式

benzoyloxy-[4]p...

~%

6-(4-methoxyphenyl)-5-pyridin-4-yl-2,3-dihydroimidazo[2,1-b][1,3]thiazole结构式

6-(4-methoxyphe...

4-(4-methoxyphenyl)-5-pyridin-4-yl-1,3-dihydroimidazole-2-thione结构式

4-(4-methoxyphe...

1,2-二溴乙烷结构式

1,2-二溴乙烷

~%

6-(4-methoxyphenyl)-5-pyridin-4-yl-2,3-dihydroimidazo[2,1-b][1,3]thiazole结构式

6-(4-methoxyphe...

5-(4-methoxyphenyl)-6-pyridin-4-yl-2,3-dihydroimidazo[2,1-b][1,3]thiazole结构式

5-(4-methoxyphe...

4-吡啶甲醛结构式

~%

5-(4-methoxyphenyl)-6-pyridin-4-yl-2,3-dihydroimidazo[2,1-b][1,3]thiazole结构式

5-(4-methoxyphe...

2-hydroxy-1-(4-methoxyphenyl)-2-pyridin-4-ylethanone结构式

2-hydroxy-1-(4-...

~%

5-(4-methoxyphenyl)-6-pyridin-4-yl-2,3-dihydroimidazo[2,1-b][1,3]thiazole结构式

5-(4-methoxyphe...

benzoyloxy-[4]pyridyl-acetonitrile结构式

benzoyloxy-[4]p...

~%

5-(4-methoxyphenyl)-6-pyridin-4-yl-2,3-dihydroimidazo[2,1-b][1,3]thiazole结构式

5-(4-methoxyphe...

4-(4-methoxyphenyl)-5-pyridin-4-yl-1,3-dihydroimidazole-2-thione结构式

4-(4-methoxyphe...

1,2-二溴乙烷结构式

1,2-二溴乙烷

~%

6-(4-methoxyphenyl)-5-pyridin-4-yl-2,3-dihydroimidazo[2,1-b][1,3]thiazole结构式

6-(4-methoxyphe...

5-(4-methoxyphenyl)-6-pyridin-4-yl-2,3-dihydroimidazo[2,1-b][1,3]thiazole结构式

5-(4-methoxyphe...

1-(4-fluorophenyl)-2-hydroxy-2-pyridin-4-ylethanone结构式

1-(4-fluorophen...

~%

5-(4-fluorophenyl)-6-pyridin-4-yl-2,3-dihydroimidazo[2,1-b][1,3]thiazole结构式

5-(4-fluorophen...

4-(4-fluorophenyl)-5-pyridin-4-yl-1,3-dihydroimidazole-2-thione结构式

4-(4-fluorophen...

1,2-二溴乙烷结构式

1,2-二溴乙烷

~%

6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑结构式

6-(4-氟苯基)-5-(4-...

5-(4-fluorophenyl)-6-pyridin-4-yl-2,3-dihydroimidazo[2,1-b][1,3]thiazole结构式

5-(4-fluorophen...

1-(4-氟苯基)-2-(4-吡啶基)乙酮结构式

1-(4-氟苯基)-2-(4-...

~%

4-fluoro-N-[3-(pyridin-4-ylmethyl)-1,3-thiazolidin-2-ylidene]benzamide结构式

4-fluoro-N-[3-(...

2-氨基-2-噻唑啉结构式

2-氨基-2-噻唑啉

未登录结构式

~%

4-fluoro-N-[3-(pyridin-4-ylmethyl)-1,3-thiazolidin-2-ylidene]benzamide结构式

4-fluoro-N-[3-(...

2-(4-甲氧基苯基)苯乙酮结构式

2-(4-甲氧基苯基)苯乙酮

~%

6-(4-methoxyphenyl)-5-phenyl-2,3-dihydroimidazo[2,1-b][1,3]thiazole结构式

6-(4-methoxyphe...

4-甲氧基苯基乙酰氯结构式

4-甲氧基苯基乙酰氯

~%

6-(4-methoxyphenyl)-5-phenyl-2,3-dihydroimidazo[2,1-b][1,3]thiazole结构式

6-(4-methoxyphe...

苯结构式

~%

6-(4-methoxyphenyl)-5-phenyl-2,3-dihydroimidazo[2,1-b][1,3]thiazole结构式

6-(4-methoxyphe...

2-氨基-2-噻唑啉结构式

2-氨基-2-噻唑啉

2-bromo-2-(4-methoxyphenyl)-1-phenylethanone结构式

2-bromo-2-(4-me...

~%

6-(4-methoxyphenyl)-5-phenyl-2,3-dihydroimidazo[2,1-b][1,3]thiazole结构式

6-(4-methoxyphe...

2-hydroxy-1-(4-methoxyphenyl)-2-pyridin-4-ylethanone结构式

2-hydroxy-1-(4-...

thiourea结构式

~65%

4-(4-methoxyphenyl)-5-pyridin-4-yl-1,3-dihydroimidazole-2-thione结构式

4-(4-methoxyphe...

benzoyloxy-[4]pyridyl-acetonitrile结构式

benzoyloxy-[4]p...

~%

4-(4-methoxyphenyl)-5-pyridin-4-yl-1,3-dihydroimidazole-2-thione结构式

4-(4-methoxyphe...

4-吡啶甲醛结构式

~%

4-(4-methoxyphenyl)-5-pyridin-4-yl-1,3-dihydroimidazole-2-thione结构式

4-(4-methoxyphe...

benzoyloxy-[4]pyridyl-acetonitrile结构式

benzoyloxy-[4]p...

甲硫基苯甲醛结构式

甲硫基苯甲醛

~0%

2-hydroxy-1-(4-methylsulfanylphenyl)-2-pyridin-4-ylethanone结构式

2-hydroxy-1-(4-...

[1-(4-methoxyphenyl)-2-oxo-2-pyridin-4-ylethyl] benzoate结构式

[1-(4-methoxyph...

4-甲氧基苯甲醛; 对甲氧基苯甲醛; 大茴香醛结构式

4-甲氧基苯甲醛; 对甲氧基苯...

benzoyloxy-[4]pyridyl-acetonitrile结构式

benzoyloxy-[4]p...

~0%

2-hydroxy-1-(4-methoxyphenyl)-2-pyridin-4-ylethanone结构式

2-hydroxy-1-(4-...

[1-(4-methoxyphenyl)-2-oxo-2-pyridin-4-ylethyl] benzoate结构式

[1-(4-methoxyph...

4-吡啶甲醛结构式

~%

[1-(4-methoxyphenyl)-2-oxo-2-pyridin-4-ylethyl] benzoate结构式

[1-(4-methoxyph...

4-甲氧基苯甲醛; 对甲氧基苯甲醛; 大茴香醛结构式

4-甲氧基苯甲醛; 对甲氧基苯...

benzoyloxy-[4]pyridyl-acetonitrile结构式

benzoyloxy-[4]p...

~%

[2-(4-methoxyphenyl)-2-oxo-1-pyridin-4-ylethyl] benzoate结构式

[2-(4-methoxyph...

[1-(4-methoxyphenyl)-2-oxo-2-pyridin-4-ylethyl] benzoate结构式

[1-(4-methoxyph...

对氟苯甲醛结构式

对氟苯甲醛

benzoyloxy-[4]pyridyl-acetonitrile结构式

benzoyloxy-[4]p...

~%

1-(4-fluorophenyl)-2-hydroxy-2-pyridin-4-ylethanone结构式

1-(4-fluorophen...

[1-(4-methoxyphenyl)-2-oxo-2-pyridin-4-ylethyl] benzoate结构式

[1-(4-methoxyph...

4-吡啶甲醛结构式

~%

[2-(4-methoxyphenyl)-2-oxo-1-pyridin-4-ylethyl] benzoate结构式

[2-(4-methoxyph...

4-甲氧基苯甲醛; 对甲氧基苯甲醛; 大茴香醛结构式

4-甲氧基苯甲醛; 对甲氧基苯...

benzoyloxy-[4]pyridyl-acetonitrile结构式

benzoyloxy-[4]p...

~%

[2-(4-methoxyphenyl)-2-oxo-1-pyridin-4-ylethyl] benzoate结构式

[2-(4-methoxyph...

[1-(4-methoxyphenyl)-2-oxo-2-pyridin-4-ylethyl] benzoate结构式

[1-(4-methoxyph...

4-甲氧基苯甲醛; 对甲氧基苯甲醛; 大茴香醛结构式

4-甲氧基苯甲醛; 对甲氧基苯...

benzoyloxy-[4]pyridyl-acetonitrile结构式

benzoyloxy-[4]p...

~49%

2-hydroxy-1-(4-methoxyphenyl)-2-pyridin-4-ylethanone结构式

2-hydroxy-1-(4-...

[1-(4-methoxyphenyl)-2-oxo-2-pyridin-4-ylethyl] benzoate结构式

[1-(4-methoxyph...

4-吡啶甲醛结构式

~%

2-hydroxy-1-(4-methoxyphenyl)-2-pyridin-4-ylethanone结构式

2-hydroxy-1-(4-...

2-氨基-2-噻唑啉结构式

2-氨基-2-噻唑啉

2-bromo-2-(4-methoxyphenyl)-1-phenylethanone结构式

2-bromo-2-(4-me...

~65%

5-(4-methoxyphenyl)-6-phenyl-2,3-dihydroimidazo[2,1-b][1,3]thiazole结构式

5-(4-methoxyphe...

2-(4-甲氧基苯基)苯乙酮结构式

2-(4-甲氧基苯基)苯乙酮

~%

5-(4-methoxyphenyl)-6-phenyl-2,3-dihydroimidazo[2,1-b][1,3]thiazole结构式

5-(4-methoxyphe...

4-甲氧基苯基乙酰氯结构式

4-甲氧基苯基乙酰氯

~%

5-(4-methoxyphenyl)-6-phenyl-2,3-dihydroimidazo[2,1-b][1,3]thiazole结构式

5-(4-methoxyphe...

苯结构式

~%

5-(4-methoxyphenyl)-6-phenyl-2,3-dihydroimidazo[2,1-b][1,3]thiazole结构式

5-(4-methoxyphe...

benzoyloxy-[4]pyridyl-acetonitrile结构式

benzoyloxy-[4]p...

甲硫基苯甲醛结构式

甲硫基苯甲醛

~65%

2-hydroxy-1-(4-methylsulfanylphenyl)-2-pyridin-4-ylethanone结构式

2-hydroxy-1-(4-...

[1-(4-methoxyphenyl)-2-oxo-2-pyridin-4-ylethyl] benzoate结构式

[1-(4-methoxyph...

4-吡啶甲醛结构式

~%

2-hydroxy-1-(4-methylsulfanylphenyl)-2-pyridin-4-ylethanone结构式

2-hydroxy-1-(4-...

Progress in the Palladium??Catalyzed α??Arylation of Ketones...

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Catalytic Oxidative 1, 2-Shift in 1, 1′-Disubstituted Olefin...

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Synthesis and structural study of benzamarones by X-ray and ...

[Mufato, Jorge D.; Vega, Daniel R.; Aguirre, Jose M.; De La Faba, Diego J.; Lantano, Beatriz Journal of Molecular Structure, 2011 , vol. 987, # 1-3 p. 119 - 125]

Pd-catalyzed synthesis of α-aryl ketones through couplings o...

[Rao, Maddali L.N.; Giri, Somnath; Jadhav, Deepak N. Tetrahedron Letters, 2009 , vol. 50, # 45 p. 6133 - 6138]

An expedient route to heterocycles through α-arylation of ke...

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