Tetrahedron letters

First synthesis of H-phosphonate oligonucleotides bearing N-unmodified bases

T Wada, F Honda, Y Sato, M Sekine

文献索引：Wada, Takeshi; Honda, Fumio; Sato, Yuichi; Sekine, Mitsuo Tetrahedron Letters, 1999 , vol. 40, # 5 p. 915 - 918

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被引用次数: 21

摘要

Oligodeoxyribonucleotides bearing H-phosphonate internucleotidic linkages and unmodified nucleobases were synthesized for the first time by the new H-phosphonate method using N-unprotected monomers. The 6-hydroxyhexyl phosphonates at both the 5′ and 3′ ends were found to be highly effective for stabilization of the H-phosphonate oligonucleotides. Solid-phase synthesis of H-phosphonate oligodeoxy-ribonucleotides ...