Enhanced aqueous solubility of long wavelength voltage-sensitive dyes by covalent attachment of polyethylene glycol

MJ Patrick, LA Ernst, AS Waggoner, D Thai…

文献索引：Patrick, Michael J.; Ernst, Lauren A.; Waggoner, Alan S.; Thai, Dung; Tai, Dean; Salama, Guy Organic and Biomolecular Chemistry, 2007 , vol. 5, # 20 p. 3347 - 3353

全文：HTML全文

被引用次数: 10

摘要

Long wavelength voltage-sensitive dyes (VSDs) called Pittsburgh (PGH) dyes were recently synthesized by coupling various heterocyclic groups to a styryl-thiophene intermediate forming extended, partially rigid chromophores. Unlike most styryl VSDs, dyes with a sulfonic acid anchor directly attached to the chromophore showed no solvatochromic absorption shifts. The limited water solubility of many long wavelength VSDs requires the use of ...