The Journal of organic chemistry

Short Enantioselective Total Syntheses of the Piperidine Alkaloids (S)-Coniine and (2 R, 6 R)-trans-Solenopsin A via Catalytic Asymmetric Imine Hydrosilylation

MT Reding, SL Buchwald

文献索引：Reding, Matthew T.; Buchwald, Stephen L. Journal of Organic Chemistry, 1998 , vol. 63, # 18 p. 6344 - 6347

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被引用次数: 86

摘要

Due to their often potent biological activities, optically active piperidine alkaloids containing a stereogenic carbon atom in the 2-position are an important group of natural products, and they have been the target of numerous synthetic strategies. 2 Prior syntheses of this type of alkaloid (vide infra) have generally involved the use of asymmetry derived from naturally occurring compounds; most often, this requirement directly prohibits the availability of both ...