Approaches to a synthesis of galbonolide B

PM Smith, EJ Thomas

文献索引：Smith, Peter M.; Thomas, Eric J. Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 21 p. 3541 - 3556

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被引用次数: 40

摘要

An approach to the C (7)–C (15) fragment of galbonolide B 2 has been completed in which the diene fragment 51 was assembled from (R)-3-tert-butyldimethylsilyloxypentan-2-one 29 by conversion into the unsaturated ester 30, acylation of the sulfone 47 using this ester, reductive desulfurisation, methylenation using a Wittig reaction and deprotection. Following model studies, the aldehyde 62, prepared by oxidation of the alcohol 51, was converted ...