Efficient syntheses of 2-(2, 6-dichloro-4-trifluoromethyl-phenyl) tetrahydrocyclopenta, tetrahydrothiopyrano, hexahydrocycloheptapyrazoles and tetrahydroindazoles
SK Meegalla, D Doller, R Liu, D Sha, RM Soll…
文献索引：Meegalla, Sanath K.; Doller, Dario; Liu, Ruiping; Sha, Deyou; Soll, Richard M.; Dhanoa, Dale S. Tetrahedron Letters, 2002 , vol. 43, # 48 p. 8639 - 8642
Two methods are described for the regiospecific synthesis of 3, 4-fused-cycloalkyl-1- arylpyrazoles; the key step is the reaction between aryl hydrazines and cyclic α- (dimethoxymethyl) ketones. The latter are obtained by BF3-promoted alkylation of ketones with trimethylorthoformate.
