gem-Difluoromethylenated biflavonoid was synthesized via the Suzuki coupling reaction. The key intermediate 6-iodonated flavone was regioselectively synthesized by the use of AgOAc/I2 under mild conditions without handling of a strongly toxic reagent. The key step was the formation of a flavone 3′-boronate using a palladium-catalyzed exchange of the corresponding 3′-iodonated flavone with a diboron reagent.
