Synthetic routes to a constrained ring analog of didemnin B

…, AJ Pfizenmayer, MM Joullié

文献索引：Mayer, Scott C.; Pfizenmayer, Amy J.; Joullie, Madeleine M. Journal of Organic Chemistry, 1996 , vol. 61, # 5 p. 1655 - 1664

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被引用次数: 20

摘要

The didemnin class of biologically active cyclodepsipeptides, isolated from a marine tunicate, has shown antitumor, antiviral, and immunosuppressive activities. Synthetic studies were undertaken to prepare a modified analog of one of the most potent congeners, didemnin B (1). The side chain of the isostatine unit was tethered into the macrocycle via a cyclohexane ring in order to provide a more rigid conformation and determine the ...