Tetrahedron letters

A new stereocontrolled, pyrylium-based route to conjugated dienynes: The first synthesis of carduusyne A

P Charoenying, DH Davies, D McKerrecher…

文献索引：Charoenying, Patchanee; Huw Davies; McKerrecher, Darren; Taylor, Richard J. K. Tetrahedron Letters, 1996 , vol. 37, # 11 p. 1913 - 1916

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被引用次数: 21

摘要

A new stereocontrolled route to conjugated dienynes is described, utilising organometallic addition to pyrylium salts followed by Wittig homologation and dehydrohalogenation. The utility of this methodology is illustrated in the first total synthesis of the marine metabolite Carduusyne A.