Tyrosine Kinase Inhibitors. 4. Structure-Activity Relationships among N-and 3-Substituted 2, 2'-Dithiobis (1H-indoles) for in vitro Inhibition of Receptor and Nonreceptor …
A series of 3-substituted 2, 2'-dithiobis (lH-indoles) were synthesized and evaluated for their ability to inhibit the tyrosine kinase activity of both the epidermal growth factor receptor (EGFR) and the nonreceptor pp60v-src tyrosine kinase, to extend the available structure- activity relationships for this series. The majority of the compounds were prepared either by reaction of 2-chloro-1-methylindole-3-carbonyl chloride with amines, followed by ...
