Antiproliferative activity of aroylacrylic acids. Structure-activity study based on molecular interaction fields
BJ Drakulić, TP Stanojković, ŽS Žižak…
文献索引：Drakulic, Branko J.; Stanojkovic, Tatjana P.; Zizak, Zeljko S.; Dabovic, Milan M. European Journal of Medicinal Chemistry, 2011 , vol. 46, # 8 p. 3265 - 3273
Abstract Antiproliferative activity of 27 phenyl-substituted 4-aryl-4-oxo-2-butenoic acids (aroylacrylic acids) toward Human cervix carcinoma (HeLa), Human chronic myelogenous leukemia (K562) and Human colon tumor (LS174) cell lines in vitro are reported. Compounds are active toward all examined cell lines. The most active compounds bear two or three branched alkyl or cycloalkyl substituents on phenyl moiety having potencies in ...
